"'Who people choose to sleep with or spend their lives with shouldn't matter, not that anyone particularly cares who I'm attracted to,' she added.
Paquin came out as a bisexual in April 2010, just four months before she and Moyer wed.
She amazed fans with her unexpected announced in a PSA video promoting the Give a Damn campaign, which features celebrities speaking out for equality.
'I'm Anna Paquin. I'm bisexual and I give a damn,' the X-Men star said on-camera during a private taping in front surprised on-lookers.
'It wasn't like it was a big secret,' she later told U.S. website Zap2it.com.
Open-minded: Paquin talked openly about her bi-sexuality, saying: 'Who people choose to sleep with or spend their lives with shouldn't matter'
'It was just a cause I cared about and privately supported, but not one that I had ever had an opportunity to speak out about in a way that would be useful.
'Obviously I know that one person's voice doesn't necessarily do that much, but I just wanted to do my bit.'
Her mature handling of her personal life shows how the former child star is old beyond her years, after being catapulted to world-wide fame when she won an Oscar at the age of 11 for Best Supporting Actress in The Piano.
Life imitated art on the set of True Blood, and after falling for her co-star and vampiric love interest, Moyer, the couple married in August last year in an intimate ceremony in Malibu.
Now happily married, they have the interesting dilemma of having to sleep with each other in character on set too.
Jackie O: Paquin was reminiscent of famous first lady and fashion icon Jackie Kennedy in this sixties inspired shot
'Maybe it should be weird, simulating sex with your husband in front of people. But it's really not,' explained Paquin.
'When it's a love scene with someone you actually love it's not, "Can I touch him here, can I touch him there?" You know what your boundaries are, or aren't I suppose.'
While the cameras don't phase her, neither do Moyer's dedicated fans who would probably happily suck Paquin's blood to get her away from their beloved Bill Compton.
'There is probably something wrong with me, but I find it amusing to watch these men and women fawn all over him,' said the lucky wife.
It’s not like anyone is really trying to do anything inappropriate. They just him to hug them… or bite them.'
Black and white beauty: The serene images perfectly capture Paquin's flawless beauty
The 41-year-old British actor, who plays vampire Bill Compton in the series, echoed her sentiments and tries to indulge some of the bizarre requests from fans.
Speaking to the new issue of Men’s Health magazine, he said: ‘I get to sign boobs a lot. I get to bite boobs occasionally, when I’m allowed.
‘If my missus is there and she approves of the person I get to bite boobs… and necks,' revealed the Essex-born actor."
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